Multilocus sequence analysis of Borrelia burgdorferi s.l. in Russia
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چکیده
منابع مشابه
Multilocus sequence analysis of Borrelia burgdorferi s.l. in Russia.
Borrelia burgdorferi sensu lato is a species complex that includes the causative agents of Lyme borreliosis (LB). Classification of the complex was greatly influenced by the method of multilocus sequence typing (MLST), proposed in 2008 and analyzing the spatial distribution of sequence types (STs). Despite the fact that Russia is the largest natural focus of LB to date, it is represented by onl...
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The clinical manifestations of Lyme disease, caused by Borrelia burgdorferi, vary considerably in different patients, possibly due to infection by strains with varying pathogenicity. Both rRNA intergenic spacer and ospC typing methods have proven to be useful tools for categorizing B. burgdorferi strains that vary in their tendency to disseminate in humans. Neither method, however, is suitable ...
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A Borrelia burgdorferi secA homologue was cloned and the complete DNA sequence was determined. The deduced protein sequence consists of 899 amino acids and shows a high degree of homology to SecA homologues from other Bacteria and photosynthetic plastids. The presence of the secA gene in Spirochetes suggests that this gene is present in most if not all major lineages within Bacteria. The ease o...
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Comparative genomics of closely related bacterial isolates is a powerful method for uncovering virulence and other important genome elements. We determined draft sequences (8-fold coverage) of the genomes of strains JD1 and N40 of Borrelia burgdorferi sensu stricto, the causative agent of Lyme disease, and we compared the predicted genes from the two genomes with those from the previously seque...
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Borrelia burgdorferi is a motile spirochete which has been identified as the causative microorganism in Lyme disease. The physiological functions which govern the motility of this organism have not been elucidated. In this study, we found that motility of B. burgdorferi required an environment similar to interstitial fluid (e.g., pH 7.6 and 0.15 M NaCl). Several methods were used to detect and ...
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ژورنال
عنوان ژورنال: Ticks and Tick-borne Diseases
سال: 2013
ISSN: 1877-959X
DOI: 10.1016/j.ttbdis.2013.02.004